Hypoxia reprograms calcium signaling and regulates myoglobin expression
نویسندگان
چکیده
Shane B. Kanatous, Pradeep P. A. Mammen, Paul B. Rosenberg, Cindy M. Martin, Michael D. White, J. Michael DiMaio, Guojin Huang, Shmuel Muallem, and Daniel J. Garry Department of Biology, Colorado State University, Fort Collins, Colorado; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Duke University Medical School, Durham, North Carolina; 4 Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota; Department of Cardiovascular Surgery, University of Texas Southwestern Medical Center, Dallas, Texas; and Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas
منابع مشابه
Both hypoxia and work are required to enhance expression of myoglobin in skeletal muscle. Focus on "Hypoxia reprograms calcium signaling and regulates myoglobin expression".
Myoglobin is an oxygen storage molecule that is selectively expressed in cardiac and slow-twitch skeletal muscles that have a high oxygen demand. Numerous studies have implicated hypoxia in the regulation of myoglobin expression as an adaptive response to hypoxic stress. However, the details of this relationship remain undefined. In the present study, adult mice exposed to 10% oxygen for period...
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